Gervais is returning to the hosting job for a fourth time but is a controversial choice because of his cutting jokes about the famous faces in attendance.
At previous ceremonies he mocked Angelina Jolie, Robert Downey Jr, Mel Gibson and Johnny Depp mercilessly.
Gervais, wearing dark sunglasses, laughed continually throughout his interview on the red carpet today prompting questions of whether the presenter had consumed any alcohol or drugs.
Asked by Ryan Seacrest what he had been taking before the show, Gervais replied: "Just a little bit of ... ummm."
Fallon replied: "Before, during, after."
Gervais wouldn't say whether he wrote new material after Rolling Stone released a piece by actor Sean Penn in which he interviewed Mexican drug kingpin Joaquin "El Chapo" Guzman.
Hours before the show Gervais posted a shirtless photo to Twitter with an obscene caption, setting the tone of what may be to come.
"Better get dressed and offend some humourless c**** I suppose," Gervais wrote.
This is Gervais's fourth time hosting the Golden Globes.
He last hosted the show in 2012. Crowd favourites Tiny Fey and Amy Poehler hosted the Globes for the last three years.
- AAP with agencies