The rapper had recently posted a photo to his Instagram that revealed his address on a luggage tag, according to followers on Twitter.
Two masked men broke into the rapper's home in the Hollywood Hills around 4.30am, according to TMZ.
They fired a volley of bullets and fled the scene on foot, leaving Pop Smoke critically injured.
He was taken to Cedars-Sinai Medical Center in West Hollywood, where he was pronounced dead, reports news.com.au.
Welcome to the Party, the lead single of his 2019 debut mixtape, Meet the Woo, was made into two remixes featuring Nicki Minaj and Skepta last August.
Pop Smoke also featured on the track Gatti with JackBoys and Travis Scott.
While fellow celebrities have alluded to jealousy in their tributes to Pop Smoke, inferring that the attack was premeditated, officials have described the incident as a "home invasion robbery".
The suspects are still at large.