Amid the small talk, viewers learned that Obama blows off steam by cursing, that his underwear is all one brand and one colour, that he shaves before he works out and that his guilty food pleasure is nachos.
"How many world leaders, you think, are just completely out of their mind?" Seinfeld asked Obama at one point.
"A pretty sizeable percentage," Obama replied.
"Some of these people, you must meet them, you'll just be chatting and you look in the eyes and go, 'Oh, this guy's gone'," Seinfeld said.
"Part of what happens is, these guys, I think the longer they stay in office, the more likely that is to happen," Obama said.
Seinfeld and Obama also talked about the drawbacks of fame versus anonymity, how to deal with hecklers, and Obama's most embarrassing presidential moment.
"This may be it," quipped the president.
The show follows Obama's appearance earlier in December on the survival adventure TV series Running Wild with Bear Grylls in Alaska to highlight the dangers of global warming, his 2014 spoof interview for online video series Funny or Die to promote Obamacare and numerous appearances on TV chat shows while in office, including The Tonight Show, The Daily Show and The View.
- AAP