Kim Kardashian West and Kourtney Kardashian in TV fistfight

Kim Kardashian West. Photo / Getty Images

Kim Kardashian West got into a fistfight with sister Kourtney Kardashian and insulted Kylie and Kendall Jenner.

The Keeping Up with the Kardashians star was involved in a bust-up with her older sister Kourtney on the opening episode of the latest series of the family's E! show.

It stemmed from a comment Kim made about beauty mogul Kylie missing walking the catwalk at Paris Fashion Week because she was "sick".

Kim had said: "If I were on my death bed, I would still show up [to appearances]."

The KKW Beauty founder then said that their mother Kris Jenner is used to Kim and Khloe "going on our death beds", before she suggested that Kourtney and Kendall don't have a strong work ethic.

Kendall then asked Kim: "And me?"

She said she doesn't include Kendall because she suffers from anxiety, but the model was still fuming.

Kim said: "No, you get anxiety and it's, like, hard."

But Kendall fired back: "Are you f***ing kidding me? I literally will come at you right now. I swear to God. I've been sick as f***, been having major panic attacks. I work my f***ing ass off when I'm sick or not."

However, Kim then turned her attention back to her spat with Kourtney - who returned to the show after saying she was going to quit - and how she never works.

Kim accused the Poosh owner of creating a "narrative about this work ethic".

Things then got really heated, and Kourtney hit back: "I will literally f*** you up."

Kim then erupted and threatened to "punch" her sibling's face, before things escalated into a physical fight.

Khloe Kardashian, Kourtney Kardashian and Kim Kardashian in a promotional shoot for the Kardashian Kollection for Sears. Photo / Supplied

Kim fumed: "What the f*** is wrong with you? Don't ever come at me like that. I swear to God, I'll punch you in your face."

Their sister, Khloe, then tried to calm everyone down, but she couldn't, and Kim proceeded to slap Kourtney several times.

Kourtney also admitted on the episode that she felt like Kim and Khloe have been against her in recent times after they tried to have it out with her.

She told the cameras: "For years, it used to be Khloe and I against Kim. And for the last, maybe, three years, it's just been such a different dynamic where it's Kim and Khloe against me."