Axel Rose last played Melbourne in 2013 as Guns N' Roses with a fill-in band, making this the original band's first Melbourne performance in 24 years, since they played Calder Park in 1993.
Some fans took to Twitter to publicise the slip up, with one fan noting: 'Guns n Roses just came out at their "Melbourne" concert yelling SYDNEY!!!... Doh'!'
The band later took to Twitter to apologise to concert-goers for the error, saying their guitar technician McBob - who introduces the band on stages around the world - messed up for the first time in 30 years.