Echoing Republican candidate Donald Trump's lewd recording from 2005, the singer reportedly joked: "Sometimes you just have to agree to disagree and grab some pussy."
"Someone take my twitter away from me," she wrote afterwards.
But most of her fans didn't seem to mind, saying it was a funny joke and that people need to "lighten up".
More from Spy:
• Brangelina reach custody agreement
• Stranger Things star's self-harm struggle
The singer is a proud Clinton supporter who has performed at the Democratic candidate's rallies and campaigned for her on social media.
Earlier today, she shared a snap of her and Clinton at a campaign rally in Iowa City back in January.
She simply captioned the photo #ImWithHer, with an emoji showing the American flag and red and blue hearts.
Don't worry, Demi. There'll be plenty more terrible tweets as the election goes on!