George Clooney has whisked his new bride off to the Seychelles for a luxury honeymoon, according to reports.

The US movie star and his new wife, Amal Alamuddin, are said to be enjoying a special vacation on a private island which is only accessible by helicopter.

Reports suggest Clooney has rented out a luxury villa on North Island for more than US$5000-per person, per night.

The exclusive resort has previously hosted Clooney's friend Brad Pitt and Angelina Jolie, as well as Prince William and the Duchess of Cambridge.

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Clooney wed Alamuddin in Venice on September 27 and the nuptials were made official during a civil service on September 29.

- AAP