Matafeo was named alongside a stacked group of contenders including I May Destroy You star and creator Michaela Coel, It's A Sin actor Olly Alexander and Sound of Metal star Riz Ahmed.
While it is early days yet in the search for the show's next big star, even just the mention of Matafeo's name on the list may delight Kiwi fans of the BBC show.
The sci-fi show began broadcasting in the BBC in 1963, and follows a Time Lord who explores the universe in a time-travelling space ship called the Tardis.
In 2017, Whittaker became the first woman to play the role. Previous actors who played the role include Matt Smith and David Tennant.
If she is picked to be the next Doctor, the role will add to Matafeo's string of high-profile successes abroad.
Her romantic comedy series Starstruck debuted on the US's HBO Max and the UK's BBC Three earlier this year and has already been picked up for a second season.
The show is co-written with other Kiwi comics, Alice Snedden and Nic Sampson.