Just before confirming Lopilato was pregnant again last year, the family experienced an horrific scare involving the health of their eldest son Noah, who was taken to the hospital in June after suffering severe burns when he was exposed to scalding hot water.
Lopilato told Argentine publication Luz the accident occurred after he climbed up onto a kitchen counter and grabbed a container of boiling water.
Although doctors feared Noah would need surgery to help him recover from the burns, the little boy bounced back, and to honour the excellent medical assistance Noah received, Buble has been making regular visits to the children's hospital where his son was treated.
"We spent all that time in the hospital watching other kids come in every single day with the same thing," the Feeling Good singer told Britain's Daily Express newspaper.
"It gives you perspective, so now I spend a lot of time at the children's hospital.
"It makes me thankful because there are so many kids and families who have had it far worse. There is nothing worse in the whole universe than your kid hurting. I try to remind (my wife) Lu that we are lucky - that it could have been worse."
- AAP