Restless fans started chanting for a refund and throwing plastic cups toward the stage, at which point Manson returned to the stage for an extended stream-of-consciousness rant punctuated by foul language.
Other strange displays of behaviour The Beautiful People singer displayed in the shortened gig included overturning an amplifier and calling the neighbouring state of New Jersey - where he's slated to play on Friday - a "s***hole," TMZ reported.
The Dope Show artist, who had a cast on his leg, abruptly left the show, which was in support of his new record Heaven Upside Down, TMZ reported, noting that security ordered fans to leave the venue.
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Concertgoer Sean Walz, 28, said: "You can't even call this a show: I've been a fan since I was five-years-old. I grew up listening to him, but he's dead to me at this point."
Victoria Kaufmann, 21, said "it was disappointing," adding that she believed Manson "was too messed up and couldn't perform" properly.
Trisha Bernardo, 32, said that the musical artist, whose real name is Brian Warner, "couldn't even talk" and that the show "was horrible".
The gig was initially scheduled for October 3, 2017, but subsequently delayed after the rocker suffered a broken leg during at show at New York City's Hammerstein Ballroom after he was injured amid a stage malfunction, the paper reported.