The 2004 flick centres around a social clique called 'the Plastics' consisting of Rachel McAdams as Regina, Amanda Seyfried as Karen and Lacey Chabert as Gretchen.
Lindsay and 30 Rock star Tina recently met for a special reunion photoshoot for an upcoming issue of Entertainment Weekly.
The ladies snapped a selfie together which Lindsay then shared on her Instagram with the caption: 'Lovely running into an inspiring, funny, beautiful old friend!!!! #tinafey.'
Lindsay has been based in London for the past couple of months preparing for her debut theatre production Speed The Plow, which debuted on Wednesday evening.
The play lifts the lid on the underbelly of Hollywood's entertainment industry and Lilo's character Karen is a secretary to a Hollywood executive who tries to manipulate her way to success.
The show also stars actors Richard Schiff and Nigel Lindsay.
In an interview with The Telegraph, the flame-haired siren admitted she was initially overwhelmed by her role of Karen, who was also portrayed by chart-topper Madonna in 1988, according to the publication.
'You know, when you think about it, I was doing other things before this, and I was travelling, and I come back and I'm looking at this thing and I'm like: "Oh f***." The whole of Act Two, I just speak throughout the whole thing.'
She added: 'It feels really cool. It feels really good. It does. It's... terrifying, at times. Because in the beginning I, like, panicked. I was like: Oh my f***, I can't say all this s***.'
- Daily Mail