The last season will air early next year.
Since the show premiered in 2007, there have been 12 spin-off series on E! including, Kourtney and Khloe Take Miami, Kourtney and Kim Take New York and Revenge Body with Khloe Kardashian.
E! television network has also released a statement about the decision.
"E! has been the home and extended family to the Kardashian-Jenners for what will be 14 years, featuring the lives of this empowering family."
"Along with all of you, we have enjoyed following the intimate moments the family so bravely shared by letting us into their daily lives."
"While it has been an absolute privilege and we will miss them wholeheartedly, we respect the family's decision to live their lives without our cameras.
Keeping Up with The Kardashians season 19 begins on E! (Sky channel 14) on Fridays from 18 September, 12pm & 8.30pm.