A lot of the criticism kicked off in response to a photo she posted on Instagram in May last year - and it has continued after the latest episodes of the reality show have aired.
Now she has shared quotes on her Instagram stories seemingly in response to the deluge of negativity she receives on a regular basis on social media.
"Next time someone tries to put you down, remember that confidence is quiet but insecurity is loud," the post read.
Another one read: "Remember you will never be criticized by someone who is doing more than you. "You will only be criticized by someone who is doing less than you."
And she thanked a TikTok user who defended her, Buzzfeed News reports.
TikTok user @mackincasey called out the use of photos comparing how Khloe looked over a decade ago.
Commenting on the video she wrote: "I don't want anyone to kiss my ass. I'm not asking for that."
"But what I am asking for is for people to realise just what articles like this [do] to someone's soul and confidence."
"I am so very grateful and appreciative of anyone who stands up to bullying or people writing [stories] simply for clickbait."