Four of the alleged offences are said to have taken place in London, while the other is alleged to have happened in Gloucestershire, in the southwest of England.
Kevin Spacey pictured leaving court after testifying in a civil lawsuit in New York on May 26, 2022. Photo / John Minchillo, AP
Robert Ainslie, head of the UK Crown Prosecution Service's Special Crime Division, said: "The CPS has authorised criminal charges against Kevin Spacey, 62, for four counts of sexual assault against three men.
"He has also been charged with causing a person to engage in penetrative sexual activity without consent. The charges follow a review of the evidence gathered by the Metropolitan Police in its investigation.
"The Crown Prosecution Service reminds all concerned that criminal proceedings against Mr Spacey are active and that he has the right to a fair trial."
The former A-lister has a new film coming out, Peter Five Eight, in which he plays a serial killer.
Spacey won the Academy Award for best actor for his performance in American Beauty, and also won the best supporting actor Oscar after starring in The Usual Suspects.
He also starred in Seven, LA Confidential and Baby Driver.