In the post, Ye shared a screenshot of a text exchange he said he had with Sean "Diddy" Combs, with the caption "Jesus is Jew."
The message from Ye appeared to show Ye claiming that Combs was controlled by Jewish people, a reference to a long-standing anti-Semitic conspiracy theory.
West also received backlash for comments he made about Jared Kushner during the rapper's recent appearance on Fox News' Tucker Carlson Tonight that were perceived as perpetuating Jewish stereotypes.
Advocacy group American Jewish Committee took to Instagram on Friday to condemn West for "rants laden with racist and antisemitic undertones" and "anti-Jewish posts."
Ye accused Jared Kushner, who is Jewish, of brokering Israeli treaties for monetary gain.
It's not the first time West has been in the spotlight for his social media antics.
In March, his Instagram account was suspended for 24 hours after he posted a slur targeting The Daily Show host Trevor Noah.
In February, West also apologised for since-deleted Instagram posts that shared messages between himself and estranged wife Kim Kardashian about her then-boyfriend Pete Davidson.
West wrote at the time that "sharing screenshots was jarring and came off as harassing Kim."