She added: "For too long, our people's voices have not been heard. It's our duty to stand together and take our power back."
Towards the end of the sketch, Kenan's character said: "When we come back, we'll talk about the presidential race between Donald Trump, Joe Biden and Kanye West."
Issa's interrupted and said: "Kanye? F him!"
On Sunday, Kanye accused the show of using "black people to hold other black people back" and promised to pray for the guest host.
He tweeted: "Ive always said SNL uses black people to hold other black people back My heart goes out to Issa Rae I'm praying for her and her family.
"I know that the twenty years of service that I've paid in the entertainment field has furthered our ability to be more successful."
He accompanied his tweet with a screenshot of Issa Rae's Google search results, in Spanish.
The 43-year-old star declared his presidential campaign on 4 July but he has only qualified to be on the ballot in 12 states.
He has instead encouraged voters to write in his name on ballots where it does not already appear.
