The couple have called time on their relationship for a second time, 15 months after they reunited, the 38-year-old actor's representative has confirmed.
The spokesperson told People: "I can confirm that Jude Law and Sienna Miller are no longer in a relationship."
Jude - who reunited with the Factory Girl
star in October 2009 following a three-year split - and Sienna, 29, are said to have split up several weeks ago but have vowed to remain friends.
One pal said: "It is mutual and amicable and they are still friends.
"It was an entirely an end-of-the relationship decision. It had run its course."
In August, it was reported that Jude and Sienna celebrated their love in a marriage blessing ceremony in Southeast Asia.
Prince Nithakong Somanith - cultural and artistic adviser to the United Nations Educational, Scientific and Cultural Organisation - met with the couple during their holiday and told them all about the ceremony, which is not legally binding, before sending them into the hills to meet the shaman.
He explained at the time: "The Baci ceremony is performed everywhere and was also performed at the Royal Court.
"It usually takes place on the morning of the wedding and is followed by the wedding blessing by monks and feasting and drinking beer and rice alcohol in the evening. Jude Law and Sienna Miller will already be man and wife in people's eyes here."
Jude - who has five children from previous relationships - split with Sienna for the first time in November 2006, almost two years after they got engaged, after he had cheated on the actress with his kids' nanny.
- BANG! Showbiz
