Now, for the first time, she's made the choice to pose fully naked in the March issue of that very same magazine.
Vanity Fair posted the shot of Lawrence lying nude on her front with a Boa constrictor snake crawling over her body on Instagram.
The magazine's fashion and style director Jessica Diehl said: "Jennifer has the perfect combination of strength, sexuality, humour and, above all, tomboy to pull this off."
According to the publication, Lawrence only started to become uncomfortable when the snake took a particular interest in her neck. The shoot ended shortly afterwards, and the Boa slipped back into its protective box.
The image was taken as part of the magazine's annual Hollywood Issue, which will this year see British stars including Eddie Redmayne, Benedict Cumberbatch, Felicity Jones and David Oyelowo on the cover.
- Independent