"There was such a backlash to when they announced it and Ryan Gosling, who I love and I just did a movie with him - he's the greatest," said Cooper, who claimed a "friend" sent him a link to a website comparing pap snaps of him and Gosling.
"When I say friend, I mean me, alone in my room, looking at the computer," Cooper joked. "And it's like him walking around and he literally looks like he's in a photo shoot, like he just came off the runway.
"And there's ones of me, and I literally look like the neighbour who never really comes out of his house, and when he does, you're like, 'Maybe you should just stay in. We don't know what he does in there!' So it's been interesting."
Cooper - who previously dated Renee Zellweger - also jokingly called being named the Sexiest Man, "the worst," adding, "it's just so awful".
"I'm finally at an age - I'm 36 years old - where I really don't care about anything like that anymore, which is a wonderful thing and then this happened and then I started to realise just how not sexy I am," he said.
Ah, bonus points for the self-deprecating humour, Cooper, but you've hardly been whacked with the ugly stick.
"I have a lot of moments where [I'm] walking out and I'll open up the door [and think to myself], 'I could do that a lot sexier,'" he laughed.
Meanwhile, Cooper also confirmed that a third Hangover film is in the pipeline.
"I think that we adhered to the formula in the second one, for those who've seen it, and the third one, I think, which would close the whole trilogy," Cooper said.
"I think it'll take place in Los Angeles and maybe not adhere to the structure. It might be different."
He also confirmed that director Todd Phillips is penning the script, with shooting due to take place next September.
Watch Cooper's interview below:
- Blogger Bites Back