"And I think we can all agree that 2016 has been a big pile of sh*t."
Just before the crowd erupted into applause, the 71-year-old Oscar winner finished with a very timely plug for her latest film.
"Above all, go see Collateral Beauty, out on Boxing Day," she said.
Unfortunately for Mirren and the rest of the Collateral Beauty cast, film critics have not been kind to the film.
Despite the impressive line-up, (Kate Winslet, Keira Knightley and Edward Norton also star) early reviews out of the US have savaged the 2016 drama, with some critics even awarding it one and zero stars.
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"It's near impossible to make a movie with no redeeming features - but damned if Collateral Beauty doesn't hit the zero-stars jackpot," Rolling Stone wrote.
"Smith ... seems fully committed to playing the role of a human frown-face emoji ... A Collateral Mess," Entertainment Weekly published.