The script, written by Lee Eisenberg and Gene Stupnitsky, who also penned The Office, will be edited to account for Ramis' passing but, as his involvement in Ghostbusters III was minor, it is unlikely to be heavily effected by the tragic news.
"There will be some repercussions," the film website reports. "(Ramis) was always great to bounce something off of, and that will certainly be missed, but it won't affect the script."
Ramis, Murray and Aykroyd were set to feature in the third Ghostbusters instalment for a "baton-passing to a trio of newcomers" but that plan must now be reconsidered.
Shooting was not scheduled to begin in 2014 as the script had not been finalised and actor deals have yet to be signed.
Ernie Hudson, who played Winston Zeddemore in the original Ghostbusters told TMZ that Ramis was "the glue" of the franchise.
"There wouldn't be a Ghostbusters without Harold Ramis. Harold pulled it together," he said.
"There can't be another Ghostbusters without Harold. There can be another 'Ghost-something'. That was always my fear, was that something would happen before we all got together."
- Independent