"It's such a horrible time while you're in office. No, I wouldn't want to be in politics; I have no interest in it."
Clooney does, however, plan to become even more involved in working with causes that are important to him.
"I believe in the political process and I believe that government at its best is designed to look after the people that can't look after themselves," he said.
"I think that's our responsibility to hold our government to task for that.
"I'm always frustrated by it and it moves incrementally forward and sometimes it's three steps backwards, but I still very much believe in the process and I will continue to be as much a part of it as I can be because I'm a citizen of the country."
Clooney's father Nick had a taste of politics - running as a Democrat in the 2004 election for a seat in the House of Representatives representing Kentucky's fourth Congressional District.
He lost the open seat to Republican Geoff Davis, and announced his career in politics was over during his concession speech.
- WENN