Amal, 44, revealed during the interview that Alexander is "a big prankster."
"You've taught him all of these lessons," she said to George, "and he's now pranking his dad back."
The Ocean's Eleven star added his son's favourite superhero is Batman, a character he once portrayed.
"I go, 'You know, I was Batman,' and he goes, 'Yeah, but not anymore,'" he joked, referring to his portrayal in 1997's Batman and Robin.
He added, "If only he knew how true that was."
The Ticket to Paradise actor previously joked about the language barrier with his twins when asked about what interests they might have later in life.
When asked whether his kids would pursue acting one day, George told Entertainment Tonight that, "They can do whatever they want."
"My guess is that they're a little smarter than me, so, they'll probably do something — they already speak three languages, so, I'm still working on English."