The actor was taken to the emergency room of the John Paul II hospital, in Olbia, Sardinia, where he had an X-ray, and wife Amal, 40, rushed to be by his side.
The actor was said to have been discharged on the same morning and he and Amal left together in a chauffeur-driven car.
A picture from La Nuova suggests that Clooney hit a car while on the motorway. The photo showed the car's windscreen smashed.
A fire extinguisher can be seen on the road but no people from the accident were involved.
Clooney relocated his family to Sardinia, the second largest Island in the Mediterranian Sea, so he could film TV mini-series Catch 22, according to The Sun.
The US actor is directing, producing and starring in the six episode mini-series based on Jospeh Heller's famous novel.
Set in Italy during World War II, Catch-22, follows the story of the artful dodger Yossarian, a bombardier for the US Air Force, who is furious because many others he has never met are trying to kill him. The series is being produced for Hulu.
