The 'Bodack Yellow' hitmaker then referenced Pete Davidson, who has been receiving hate online ever since his engagement to Ariana Grande ended in October, and who took to social media on Saturday to post a worrying message in which he said he "doesn't want to live on this earth any more."
She continued: "Just earlier, you just saw how Pete Davidson was talking about how he don't even want to be on this earth because mad people be coming at him every single day. I wouldn't want my baby father to have that feeling because of millions of people be bashing him every day. That's a nasty feeling, and I wouldn't want that.
"God could give me and bring me the most perfect, glamorous, fabulous man. That perfect, glamorous, fabulous, perfect man is not going to love my child the same way her father loves my child.
"So I don't like that bulls**t because I know how painful it is when you have millions of people bashing you every single day. I don't like that, and it doesn't make me feel any better. Period."
Meanwhile, Offset's onstage outburst comes after he took to Instagram to admit he had been "selfish and had messed up".
He said in a video: "I only got one birthday wish and that's to get my wife back Cardi.
"We're going through a lot of things right now, a lot of things in the media. I want to apologise to you Cardi. I embarrassed you. I made you go crazy.
"I was partaking in activity that I shouldn't have been partaking in. You know what I'm saying? For breaking your heart, for breaking our promise, for breaking God's promise and being a selfish, messed up husband.
"I'm trying to be a better person. I want to get this off my shoulders. I want to get this off my back. I apologise to you Cardi. I love you."
-Bang! Showbiz