The internet has lapped up the steamy pic and his 2.1 million followers have commented on the post declaring their appreciation of his tanned booty.
One follower even said the snap was, "Life changing".
Being "clean" more than likely refers to Stamos' addiction to alcohol and drugs, including the prescription sleeping drug Ambien which he said was harder to quit than alcohol.
Lori Loughlin (Rebecca), John Stamos (Jesse) from Full House. Photo / Getty
After being arrested in 2015 for driving under the influence, he attended a 30 day inpatient stint in rehab and has reportedly been clean ever since.
Well Mr. Stamos, we can't think of a better way for you to celebrate your sobriety than getting in your birthday suit and sharing your beautiful behind with the world.