Estate agent Savills describe the £4.95 million, six-bedroom home as "ideal for those who enjoy entertaining", thanks to its tennis court, heated outdoor pool, hot tub, billiards room, cinema, dance studio and gymnasium.
Cruise, who for three years lived in Hertfordshire with Nicole Kidman and their children while making Stanley Kubrick's Eyes Wide Shut in 1999, has recently put several properties up for sale.
Cruise, 53, married Dawson's Creek actress Holmes in a Scientology ceremony at Odescalchi Castle, in Bracciano, Italy, in November 2006.
The couple, who have a daughter, Suri, divorced six years later.
The actor sold his apartment in Manhattan's East Village for more than Tom Cruise is selling his West Sussex mansion close to the Church of Scientology's British headquarters £2 million three years ago.
His Beverly Hills estate, bought in 2007 for around Tom Cruise is selling his West Sussex mansion close to the Church of Scientology's British headquarters £20 million, is rumoured to be available for around twice that sum.
Buyers with £40 million to spare might also be interested in the Mission: Impossible star's Rocky Mountain compound in Telluride, Colorado.
However, it is too late to bid for his two-residence compound in Laurel Canyon, Los Angeles, after it was snapped up for close to £8 million by Desperate Housewives star Eva Longoria in October.