O'Riordan, who was born in Limerick, last posted a picture of herself with her cat on Twitter on January 4 with the caption: "Bye bye Gio. We're off to Ireland."
Her band had recently played in South America, and she tweeted pictures of fans in Lima, Peru in December.
The Cranberries last released an album in early 2017, but a US and European tour was cancelled in July because of health reasons concerning O'Riordan.
The band said she was suffering from an "ongoing back problem" and that doctors had advised her to pull out of all her upcoming gigs.