Just a month ago, Khloe was optimistic that the party would happen, and suggested they could do "rapid testing".
Responding to a follower who asked her if it will be affected by the pandemic, she wrote: "I pray not! I think it will have to be way smaller obviously.
"And I'm totally fine with that. But we're definitely celebrating Christmas! It will just have to be small and safe. Maybe do rapid testing before … We have to think of what is safest."
In October, the Kardashian/Jenner clan made the news after Khloe's sister Kim Kardashian West rented out an entire island in French Polynesia for her 40th birthday celebrations, amid the pandemic.
Kim's guest list included her siblings - Kourtney, Khloe, and Rob Kardashian, as well as Kendall and Kylie Jenner - her mother Kris Jenner, Kris' boyfriend Corey Gamble, Khloe's ex Tristan Thompson, and Kendall's beau Devon Booker.
Family friend La La Anthony was also in attendance, as was Kourtney's former partner Scott Disick and their eldest child Mason, 10.
Kim's husband Kanye West - with whom she has North, seven, Saint, five, Chicago, two, and 18-month-old Psalm - was not present for her actual birthday because of prior work commitments, but joined the trip for the final few days.
TMZ claimed Kim specifically picked out an island that hadn't seen any cases of coronavirus since the pandemic began, and asked all of her guests to quarantine for two weeks before the trip and get multiple tests.