Actor and comedian Jack Whitehall wrote: "So sad about Sean Lock. He was such a special comedian. One of the quickest, most naturally witty people I've ever worked with. Worlds a less funny place without him. RIP. "
The Twitter account for 8 Out of 10 cats said the late comedian was a "comedy genius".
"Sean Lock was a brilliant writer, a phenomenal stand-up, a comedy genius.
"We will miss him greatly. There was no-one like him."
And comedian David Mitchell said he was "shocked and sad" to hear the news of Lock's death.
"It was always a privilege and inspiration to work with him. The world should have had many years of his hilarious creativity. RIP."
Jimmy Carr said the news was "brutal" in a tweet, and shared the song Keep Me In Your Heart by Warren Zevon.
"I loved him so much. I'm watching clips of him right now - laughing & crying. I'll miss him so much."
Lock said in 2010 that he was diagnosed with skin cancer aged 27 after years of working on a building site, prior to his career in comedy in 1990. According to reports, Lock died of a different form of cancer.
Lock is survived by his wife Anoushka Nara Giltsoff and his three children.
