The comments attributed to the former teen model sparked debate on gossip sites and among news outlets, as critics poked fun at Theron for apparently feeling sorry for herself.
But the actress insists most people misunderstood what she was trying to say.
Speaking to Access Hollywood at the premiere of her new film, The Huntsman: Winter's War, on Monday night, the Oscar winner said: "It was such an incredible misquote. I'm somewhat shocked by how I got so misquoted.
"What I was really trying to say was people always ask me why I play so many characters that are so deconstructed and my point with that was that how many characters really are there out there for a woman wearing a gown? You have to kind of play real people."
She added: "It's always somewhat shocking when you do those things (magazine interviews) because context is everything, and if somebody doesn't really get that or it doesn't translate, people can really kind of read stuff so wrongly ... I couldn't be more humbled by the career I've been given."
Theron also told Extra: "I've never really spoken in that way... The idea that I would ever say anything that made it sound like I was ungrateful for the career that I have today ...
"That was rough, that was rough reading that."
- WENN