Jeff Bridges said "John Heard- what a wonderful actor. We were in the movie Cutter's Way together & I got to experience his artistry and dedication first hand."
John Heard starred in the smash hit Home Alone, with actress Catherine O'Hara.
Cher and Elizabeth Perkins also took to social media to mourn the death of their friend.
Rest peacefully, Mr. John Heard. You were the perfect foil, perfectly sly & a perfect gentleman. Many prayers to his family and children. ❤️ pic.twitter.com/vTdEeZThfU
— Elizabeth Perkins (@Elizbethperkins) July 22, 2017
Comedian Marlon Wayons, who starred with Heard in White Chicks, said they "shared a lot of laughs".
"Thank you for all your contributions to our beloved industry," the comedian wrote on Instagram. "May you live forever through your vast body of work."
Heard also made a name for himself after starring in Big with Tom Hanks, Beaches opposite Bette Midler, The Sopranos and Battlestar Galactica, among other roles on the big and small screens.
But it was his role in Home Alone where Heard was most remembered, playing Peter McCallister - the dad to Macaulay Culkin's Kevin.
Heard was nominated for an Emmy in 1999 for his role in The Sopranos.
The actor had been married three times and is survived by three children.