Lee, who is friends with Jenner and co-stars together with him and Carter on The Hills: New Beginnings, says he wondered "what the f**k just happened" when photos of her hook-up with Cyrus were published over the weekend.
Jenner commented on photos of the girls together, writing "Hot girl summer" before following up yesterday with a post on his own account which read: "Don't let yesterday take up too much of today."
Lee then chimed in sarcastically suggesting he and Jenner could "round this scandal out and post a pic of us making out."
Jenner then replied writing, "Watch out! Pics of Liam and I holding hands on the beach coming soon."
Cyrus then trolled Jenner by telling him to "Go take a nap in your truck and cool off. #HotGirlSummer."
Lee's comments come after Cyrus, 26, and Hemsworth, 29, on Sunday confirmed their eight-month marriage and decade-long relationship was dead and buried, after photos of her kissing Carter during a vacation in Italy were made public.
Cyrus' rep released a statement on Sunday saying the former Hannah Montanna star and Hemsworth had "agreed to separate at this time" after deciding "this is what's best while they both focus on themselves and careers. They still remain dedicated parents to all of their animals they share while lovingly taking this time apart. Please respect their process and privacy."
- Additional reporting by The Daily Pop