Voted for by members of the Screen Actors Guild union, the top honour - cast in a motion picture - went to American Hustle.
Other winners included Cate Blanchett for her role in Blue Jasmine and Matthew McConaughey for Dallas Buyers Club.
Brit Maggie Smith meanwhile took home the award for best female in a drama series for her role in Downton Abbey.
Here's the full list of winners:
Cast in a motion picture: American Hustle
Male actor in a leading role: Matthew McConaughey, Dallas Buyers Club
Female actor in a leading role: Cate Blanchett, Blue Jasmine
Male actor in a supporting role: Jared Leto, Dallas Buyers Club
Female actor in a supporting role: Lupita Nyong'o, 12 Years a Slave
Male actor in a comedy series: Ty Burrell, Modern Family
Female actor in a comedy series: Julia Louis-Dreyfus, Veep
Ensemble in a comedy series: Modern Family
Male actor in a TV movie or miniseries: Michael Douglas, Behind the Candelabra
Female actor in a TV movie or miniseries: Helen Mirren, Phil Spector
Male actor in a drama series: Bryan Cranston, Breaking Bad
Female actor in a drama series: Maggie Smith, Downton Abbey
Ensemble in a drama series: Breaking Bad
- Independent