Seven years after the episode first aired it has become a serious headache for the real-life owners of the home in Albuquerque, New Mexico, which attracts thousands of fans searching for souvenirs and trophy photos.
Joanne Quintana, told KOB 4, the problem had become so serious she felt compelled to seal off the home behind an imposing fence.
She said: "We feel like we can't leave because when we do something happens. And that's ridiculous."
Frank Sandoval, who runs Breaking Bad RV Tours, said he has become almost a private police force for the home and regularly shoos people from the property.
"We hear about it on a daily basis, so much so that we've gone up on the roof to pull pizza's down," he said.
The home can attract hundreds of Breaking Bad fans in a single day and Ms Quintana, whose mother owns the property, said she had endured years of rudeness and trespassing, with some fans stealing rocks from her landscaping as souvenirs.
She said: "They feel the need to tell us to close our garage, get out of the picture - tell us what to do on our own property.
"If you want rocks go to the desert, they're free".
Ms Quintana added: "We don't want to gate ourselves in, we're the ones who are being locked up. We did nothing wrong."
In a 2012 interview with Jimmy Kimmel, Bryan Cranston has described the pizza throwing scene as one of his favourites on the show.
The actor said as it involved him attempting to lob the pizza onto the roof blind, the show's production team had blocked off several hours so he could have multiple attempts to get it right.
But Cranston revealed he managed to land the pizza on the roof at his first attempt and that is the take that appears in the series.
