Messages sent to Kutcher's and Moore's publicists were not immediately returned.
Moore, 50, and Kutcher, 34, created the DNA Foundation, also known as the Demi and Ashton Foundation, in 2010 to combat the organised sexual exploitation of girls around the globe. They later lent their support to the United Nations' efforts to fight human trafficking, a scourge the international organisation estimates affects about 2.5 million people worldwide.
Moore was previously married to actor Bruce Willis for 13 years. They had three daughters together Rumer, Scout and Tallulah Belle before divorcing in 2000. Willis later married model-actress Emma Heming in an intimate 2009 ceremony at his home in Parrot Cay in the Turks and Caicos Islands that was attended by their children, as well as Moore and Kutcher.
Kutcher has been dating former That '70s Show co-star Mila Kunis.
The divorce filing was first reported by People magazine.
-AP