NBC Entertainment chairman Robert Greenblatt is delighted Ariana has agreed to join the production.
He said in a statement: "We're absolutely thrilled to round out our all-star Hairspray Live! cast with Ariana Grande, one of the biggest recording artists in the world.
"She's also a Broadway baby at heart, having debuted on Broadway when she was 15, and will be fantastic in the delightful role of Penny Pingleton. We look forward to her millions of fans seeing yet another side to this multifaceted performer and we welcome her to this incredible ensemble of artists."
Ariana will feature alongside a star-studded cast in the production, which also includes Martin Short, Derek Hough, Harvey Fierstein, Kristin Chenoweth and Jennifer Hudson.