Doctors warned her that she might not be able to conceive a child naturally - but she and comedian/actor husband Taran Killam welcomed daughter Shaelyn in 2009, and their second child, a son, was born earlier this year (15).
Although Smulders hasn't had another cancer scare since then, she's not yet ready to declare herself completely free from the disease.
"I don't think I'll ever feel like I'm cancer-free. Now that I'm five years out, I'm trying to think of it as a positive thing and what can I learn from it. And if I can create more awareness, I'll do it."
Smulders has been busy lately promoting the blockbuster film The Avengers: Age of Ultron.
• The Avengers: Age of Ultron is now screening in New Zealand cinemas.
- WENN