"We've turned that laughter and ridicule into oxygen and wind at our back," they said.
The twins say they aren't leaving anything to chance when it comes to protecting their digital fortune.
Given it is a digital currency, Bitcoin is kept in an electronic "wallet", that can only be accessed with the matching private key or password.
Anyone who can get access to that key can then take the Bitcoin.
The Winklevosses came up with a their own system to protect their keys.
They printed off their keys and cut them up into pieces before storing them in envelopes in safe deposit boxes across the US.
If anyone happens to steal one envelope, the person would not have access to the entire private key.
The twins did try to create an ETF or an Exchange Traded Fund for the cryptocurrency, which would have opened it up to institutional investing.
That didn't happen as the US Securities and Exchange Commission rejected the application, citing the possibility of fraud.
The twins, who also competed as rowers in 2008 Beijing Olympics, still don't get close to their arch-nemesis Zuckerberg's net worth of $70 billion.