Tobacco companies are increasingly dependent on both a shrinking customer base and fewer numbers of loyal consumers.
One small bright spot for the industry has been the rise of e-cigarettes. Both Reynolds American and British American Tobacco have been dipping their toes into the e-cig market.
But e-cigs are still a niche market - CDC data shows that only 3.7 per cent of adults use them regularly, although they do seem to be rapidly growing in popularity among younger smokers.
The research is unclear, however, on how the growth of e-cigarettes could alter Big Tobacco's bottom line.
Some studies have shown that people who use e-cigs reduce their overall tobacco intake, while others have found evidence that for young people, vaping can be a steppingstone to regular cigarette use.
Further muddying the waters is evidence that most teens who use e-cigarettes opt for flavoured products that are free of nicotine. How that might affect their later chances of tobacco use remains unclear.
But the Reynolds American/British American Tobacco merger would allow the companies to consolidate their work on e-cigarettes, potentially leading to new products that are more attractive to consumers. It would also give the new tobacco giant a larger global footprint, enabling it to better tap into foreign markets where tobacco use trends are very different than in the United States.
According to the World Health Organisation, 1.1 billion humans - 14 per cent of the world's population - smoked tobacco last year.