Bucking the trend were shares of Merck and Pfizer following a meeting of some of the nation's drug makers with Trump. Trump said his intention to ease regulations and lower taxes will outweigh any negative impact from the lower drug prices he is demanding on corporate profits, according to Bloomberg.
Lilly and Merck said by email after the meeting that they were encouraged by Trump's focus on innovation, Reuters reported.
"Tax, deregulation-those are things that could really help us expand operations," Lilly CEO Dave Ricks said, according to Reuters
Shares of UPS dropped, trading 6.1 per cent lower as of 1.32pm in New York, after the parcel delivery company offed a disappointing full-year profit forecast.
Shares of Under Armour sank, trading 21.6 per cent weaker as of 1.33pm in New York, after the company's full-year sales outlook fell far short of expectations.
Meanwhile, Federal Reserve policy makers began their two-day meeting, at which they are not expected to lift interest rates.
"At the moment there's incredible uncertainty surrounding fiscal policy and the potential for stimulus and the composition of that," Paul Ashworth, an economist at Capital Economics, told Reuters. "The Fed can't react until it knows what to react to."
In Europe, the Stoxx 600 Index ended the session with a 0.7 per cent fall from the previous close.
The UK's FTSE 100 Index fell 0.3 per cent, while France's CAC 40 Index gave up 0.8 and Germany's DAX Index dropped 1.3 per cent.