In response to Facebook user Marcel Rukeltukel's question on where the website was heading, the billionaire - net worth US$35 billion ($52.1 billion) - said helping people share information was one of his main aims, especially using video.
"There are a few important trends in human communication that we hope to improve," he said.
"First, people are gaining the power to share in richer and richer ways. We used to just share in text, and now we post mainly with photos. In the future video will be even more important than photos. After that, immersive experiences like virtual reality will become the norm.
"And after that, we'll have the power to share our full sensory and emotional experience with people whenever we'd like.
"Second, people are gaining the power to communicate more frequently. We used to have to be with someone in person. Then we had these bulky computers. Now we have these incredible devices in our pockets, but we only use them periodically throughout the day.
"In the future, we'll have augmented reality and other devices that we can wear almost all the time to improve our experience and communication.
"Our lives improve as our communication tools get better in many ways. We can build richer relationships with the people we love and care about. We know about what's going on in the world and can make better decisions in our jobs and lives.
"We are also more informed and can make better decisions collectively as a society. This increase in the power people have to share is one of the major forces driving the world today."
The 31-year-old also took questions from famous people, including movie actor Arnold Schwarzenegger, who asked about his exercise programme.
"I make sure I work out at least three times a week - usually first thing when I wake up," Zuckerberg said. "I also try to take my dog running whenever I can."
He added that "the machines won't win", in reference to one of Schwarzenegger's most famous films, The Terminator.
Physicist Stephen Hawking asked him which of the "big questions in science" the technology entrepreneur would like to know the answer to and why.
"I'm most interested in questions about people," Zuckerberg said. "What will enable us to live forever? How do we cure all diseases? How does the brain work? How does learning work and how can we empower humans to lean a million times more?
"I'm also curious about whether there is a fundamental mathematical law underlying human social relationships that governs the balance of who and what we all care about."
He told author Arianna Huffington there would be a "trend towards richness and speed" among news organisations in publishing content.
In another answer, he said people would read more news, but clicking a link online took too long to load.
