Gains in AT&T and Nike helped lift the Dow, up 2.9 per cent and 1.4 per cent respectively. Merck and Chevron were the Dow's biggest decliners, down 0.9 per cent and 0.7 per cent.
The CBOE Volatility index, Wall Street's so-called fear gauge, dropped 3.6 per cent to 19.60.
"Yellen is an excellent choice," Charles Schumer of New York, the Senate's No. 3 Democrat, said via Twitter. "I believe she'll be confirmed by a wide margin."
Separately, the minutes of the latest Fed meeting showed that most policy makers support easing its bond-buying program this year.
"Conditional on their respective outlooks, most participants judged that it would likely be appropriate to begin to reduce the pace of the Committee's purchases of longer-term securities this year and to conclude purchases in the middle of 2014," according to minutes from the September 17-18 FOMC meeting released today.
"A couple of participants thought it appropriate for the first reduction in the pace of asset purchases to occur later, and another specified that purchases likely would continue past midyear 2014; in contrast, a couple of participants thought that the program should be ended considerably sooner than the middle of next year," the minutes showed.
Shares of Alcoa jumped 4.1 per cent after the aluminium producer produced results that surpassed expectations.
"You see the increased importance of the downstream business and the continued growth and profitability," Chairman and Chief Executive Officer Klaus Kleinfeld told Bloomberg News on Tuesday. "The share price is undervalued and has not built in the repositioning that we are undergoing but I believe it will get there."
In Europe, the Stoxx 600 Index closed 0.6 per cent lower from the previous close. France's CAC 40 slipped 0.2 per cent, Germany's DAX slid 0.5 per cent, and the UK's FTSE 100 fell 0.4 per cent.