Europe's Stoxx 600 Index ended the day with a 0.2 per cent decline from the previous session.
The euro dropped 1.1 per cent to US$1.2388 at 3.01pm in New York, while the US Dollar Index, a gauge of the greenback against six major counterparts, advanced nearly 1.3 per cent for its biggest climb of 2012, according to Bloomberg.
In late trading in New York, the Dow Jones Industrial Average barely budged, last up 0.02 per cent, while the Nasdaq Composite Index rose 0.25 per cent. The Standard & Poor's 500 Index was 0.20 per cent lower.
"The genesis of the economic decline we're seeing is Europe. It is spilling everywhere," Stephen Massocca, managing director at Wedbush Morgan in San Francisco, told Reuters.
"The market's main focus continues unchanged and that is going to be the European debt crisis. I still think that is going to be the big news story that will have the greatest impact on stock movements."
Ahead of key US monthly employment data due tomorrow, today's reports offered a few brighter-than-expected spots.
Applications for jobless benefits dropped 14,000 in the week ended June 30 to 374,000, Labor Department figures showed. Private employers increased payrolls by 176,000 last month, according to ADP Employer Services data.
"While tomorrow's employment numbers may not be great, it is beginning to look like the labour market is not nearly as weak as feared," Joel Naroff, chief economist at Naroff Economic Advisors in Holland, Pennsylvania, told Reuters.