In afternoon trading in New York, the Dow Jones Industrial Average shed 0.25 per cent, the Standard & Poor's 500 Index fell 0.78 per cent and the Nasdaq Composite Index dropped 1.44 per cent.
Profit for S&P 500 companies will rise 17 per cent in the third quarter and expand 18 per cent to a record US$99.76 for all of 2011, according to analyst estimates compiled by Bloomberg yesterday.
About three quarters of the S&P 500 companies which reported results since October 11 surpassed analysts' expectations.
In Europe, the Stoxx 600 Index rose 0.6 per cent for the day.
French president Nicolas Sarkozy headed for Frankfurt in an effort to resolve a stalemate with Germany, adding to uncertainty about progress in the talks on measures to end Europe's debt crisis ahead of this weekend's summit of European leaders.
Paris and Berlin don't agree on how to bolster the European Union's bailout fund, and the dispute is stalling negotiations, Sarkozy said on Wednesday.
"In Germany, the coalition is divided on this issue. It is not just Angela Merkel who we need to convince," Sarkozy told the parliamentarians at a lunch meeting, according to Charles de Courson, one of the legislators present, Reuters reported.
Meanwhile, Bank of England policy makers voted unanimously to boost the size of their asset-purchase stimulus, according to minutes of their October 6 meeting released today.
Moody's downgraded Spain's credit rating by two notches, while in Greece mass protests against the nation's austerity measures turned violent.