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Home / Business

Drug firms put profits before discoveries, experts claim

By Jeremy Laurence
Independent·
8 Aug, 2012 05:50 PM3 mins to read

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Photo / Thinkstock

Photo / Thinkstock

The multibillion-pound pharmaceutical industry has spent the last decade developing new drugs which have produced little benefit and caused considerable harm, experts say.

The claim that there is an "innovation crisis" in pharmaceuticals because of the difficulty and expense of discovering new drugs is a myth fostered by an industry whose chief focus is on marketing, they add.

Counter to drug industry claims that the pipeline of new drugs is running dry, the number of new drugs being licensed each year has remained at between 15 and 25. But most involve minor tweaks to existing drugs, designed to grab a slice of an existing market rather than offering genuine therapeutic innovation.

Independent reviews suggest 85 to 90 per cent provide little benefit over existing treatments with some, such as Vioxx, the painkiller, and Avandia, the diabetes drug, causing serious side effects which led to their withdrawal in Europe.

Writing in the British Medical Journal, Professor Donald Light from the University of Medicine of New Jersey and Joel Lexchin from York University in Toronto say the situation has remained the same for 50 years. The incentives for drug development are wrong and have skewed the behaviour of the industry.

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"This is the real innovation crisis: pharmaceutical research and development turns out mostly minor variations on existing drugs and most new drugs are not superior on clinical measures. [They] have also produced an epidemic of serious adverse reactions that have added to national healthcare costs," they say.

More is spent on marketing (25 per cent of revenues) than on discovering new molecules (1.3 per cent). Drug industry claims that the cost of bringing a new drug to market is £1 billion ($1.9 billion) and is unsustainable are exaggerated, they claim.

Research and development costs did rise between 1995 and 2010 by US$34.2 billion ($42 billion), they concluded, but revenues increased six times faster - by US$200 billion. Companies avoid mentioning this revenue return, they said, adding that up to 80 per cent of industry spending is on promotion.

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The authors call for licensing authorities around the world to stop approving new drugs of little therapeutic value. They suggest large cash prizes should be awarded for genuinely new therapeutic agents in lieu of patent protection.

The European Medicines Agency, which licenses drugs in the UK and Europe, keeps certain data about their safety and efficacy secret. Yet 29 per cent of new biological agents approved by the EMA received safety warnings within the first 10 years.

In a second paper, researchers from the London School of Economics in Britain argue that drug manufacturers should be made to demonstrate their products are superior to existing treatments before being granted a licence, rather than, as now, superior only to a placebo.

Stephen Whitehead, chief executive of the Association of the British Pharmaceutical Industry, said: "We strongly disagree with the claims made in these papers. Medical research has always rested on iterative and gradual innovation rather than breakthrough advances which are very rare."

- Independent

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