Slowing growth elsewhere, notably in China, has become the focus. A report showed China's imports plunged a larger-than-expected 20.4 percent from a year earlier to US$145.2 billion last month, after a 5.5 percent slide in August. Exports fell 3.7 percent, which was less than expected.
"The big concern is not rising interest rates anymore, it's slowing growth and corporate profits," Patrick Spencer, equities vice chairman at Robert W Baird & Co in London, told Bloomberg. "Earnings are starting this week and some of the biggest banks are reporting, so that is going to set the scene."
In New York trading at about 2.55pm, the Dow Jones industrial average fell 0.1 percent, the Standard & Poor's 500 Index slid 0.4 percent, while the Nasdaq Composite Index declined 0.5 percent.
In the Dow, declines in shares of United Technologies and those of IBM, down 1.1 percent and 1 percent respectively, outweighed gain in shares of UnitedHealth and those of Goldman Sachs, last up 1.8 percent and 1 percent respectively.
The data from China lifted the appeal of US Treasuries, pushing yields on the benchmark 10-year note three basis points lower to 2.06 percent.
"I doubt 10-year Treasury yields will exceed 2.3 percent by year-end given ongoing fears that weaker emerging-market growth will spill over to developed economies," Nick Stamenkovic, a fixed-income strategist at broker RIA Capital Markets in Edinburgh, told Bloomberg.
In Europe, the Stoxx 600 Index ended the session with 0.9 percent drop from the previous close. The UK's FTSE 100 Index fell 0.5 percent, Germany's DAX Index shed 0.9 percent, while France's CAC 40 Index sank 1 percent.