Gains in shares of Walt Disney, last up 1.1 per cent, and JPMorgan Chase, last up 0.9 per cent outweighed declines in shares of AT&T, down 1.7 per cent, and McDonald's, down 0.9 per cent.
Shares of AT&T were down after the company on Sunday said it agreed to buy DirecTV for US$48.5 billion.
"Strategically, this makes a lot of sense for AT&T," Jan Dawson, an analyst with Jackdaw Research in Provo, Utah, told Bloomberg News. Gaining a satellite-TV provider "lets them go national with a video offering that matches their wireless reach."
Shares of Pfizer rose, last up 0.8 per cent, after AstraZeneca rejected Pfizer's latest takeover deal. Shares of AstraZeneca plunged 11.1 per cent.
"Pfizer's chances are going down, despite its offer of a higher price," Erik Gordon, professor at the University of Michigan's Ross School of Business, told Reuters.
Shares of other drug makers slid as a result. Share of GlaxoSmithKline fell 1.4 per cent while Novartis gave up 0.6 per cent.
Europe's Stoxx 600 Index ended the day with a 0.1 per cent decline from the previous close. The UK's FTSE 100 fell 0.2 per cent. Germany's DAX and France's CAC 40 each added 0.3 per cent.
Investors will eye minutes from the US Federal Reserve's latest meeting, scheduled to be released on Wednesday. The same day Chairman Janet Yellen is set to deliver a commencement address to NYU graduates at Yankee Stadium.
In Europe, borrowing costs are widely expected to fall in June. Following European Central Bank President Mario Draghi's signal earlier this month that the bank would be "comfortable" with easing monetary policy in June, 90 per cent of economists polled by Bloomberg News now predict the ECB will follow through.