Fresh takeover deals also added momentum in an otherwise anxious market.
Rio Tinto's American Depository Receipts were last up 5.8 per cent after Bloomberg reported that Glencore may approach the Australian miner in a bid to agree on a friendly merger which would create the world's largest mining group.
Shares of CareFusion soared, last up 23.2 per cent, after Becton Dickinson agreed to buy it for US$12.2 billion in cash and stock. Shares of Becton Dickinson gained 7.1 per cent.
In late afternoon trading in New York, the Dow Jones Industrial Average fell 0.20 per cent, the Standard & Poor's 500 Index slipped 0.11, while the Nasdaq Composite Index shed 0.31 per cent.
Declines in shares of Nike and those of UnitedHealth, down 1.5 per cent and 1 per cent respectively, led the Dow lower.
"Despite the good Hewlett Packard news and other (merger) activity there's nervousness in general," Rick Meckler, president of LibertyView Capital Management in Jersey City, New Jersey, told Reuters. "Before earnings there's a lot of short-term trading going on and we have increased volatility."
Alcoa is scheduled to report earnings after the close of the market on October 8.
To be sure, investors remained optimistic about the world's largest economy and upside for Wall Street.
"The recovery is alive and well, and while there are still risks we need to keep an eye on, fundamentals suggest we're in pretty good shape and could continue to move higher," John Carey, portfolio manager at Pioneer Investment Management in Boston, told Reuters.
In Europe, the Stoxx 600 finished the day with a 0.2 per cent gain from the previous close. Earlier in the session, the index had climbed as much as 0.8 per cent. France's CAC 40 added 0.1 per cent, Germany's DAX increased 0.2 per cent, while the UK's FTSE 100 Index advanced 0.6 per cent.
A government report showed German factory orders dropped more than expected in August, while a separate report by Sentix showed investor confidence in the euro zone dropped more than anticipated in October