US business travel spending is expected to reach $296 billion by the end of this year and climb 5.2 per cent next year, according to the Global Business Travel Association, a trade group.
There were 250 companies signed up with Airbnb to manage business travel in 2015.
Last year, the number of people using the site for business purposes tripled and is expected to quadruple this year, said David Holyoke, the head of Airbnb's business travel division.
There are now more than 250,000 companies using it, including Alphabet, Domino's Pizza and Morgan Stanley.
Airbnb is hoping to benefit from younger professionals' penchant for mixing business with leisure. It said half of people using Airbnb for business travel prolong their reservations through Saturday night. "As millennials advance in the workforce, we're seeing incredible growth," said Holyoke.
"These young business people want to feel at home on the road."
The company closed a funding round last month that valued the business at about $31 billion, Bloomberg reported at the time. This makes it more valuable than Hilton Worldwide Holdings, Hyatt Hotels and Wyndham Worldwide. To remain ahead of these hotel giants, Airbnb will need to draw in more lucrative travelers, including corporate jet setters.